Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis.

Background: Myostatin is a regulator of muscle size. To date, there have been no published studies focusing on the relation between myostin levels and myopenia in rheumatoid arthritis (RA). Objective: Evaluate the value of serum myostatin as a biomarker of cachexia and low skeletal muscle mass (LSMM) in RA patients, along with whether high serum myostatin is associated to these conditions after adjusting for potential confounders. Methods: This cross-sectional study included 161 female RA patients and 72 female controls. In the RA group, we assessed several potential risk factors for LSMM and rheumatoid cachexia. Dual-energy X-ray absorptiometry was used to quantify the skeletal muscle mass index (SMMI) (considering LSMM ≤ 5.5 kg/m2) and the presence of rheumatoid cachexia (a fat-free mass index ≤ 10 percentile and fat mass index ≥ 25 percentile of the reference population). Serum myostatin concentrations were determined by ELISA. To identify a cut-off for high serum myostatin levels, we performed ROC curve analysis. Multivariable logistic regression analysis was used to identify the risk factors for LSMM and rheumatoid cachexia. The risk was expressed as odds ratios (ORs) and their 95% confidence intervals (95% CIs). Results: Compared to the controls, the RA group had a higher proportion of LSMM and exhibited high serum myostatin levels (p < 0.001). ROC curve analysis showed that a myostatin level ≥ 17 ng/mL was the most efficient cut-off for identifying rheumatoid cachexia (sensitivity: 53%, specificity: 71%) and LSMM (sensitivity: 43%, specificity: 77%). In the multivariable logistic regression, RA with high myostatin levels (≥17 ng/mL) was found to increase the risk of cachexia (OR = 2.79, 95% CI: 1.24-6.29; p = 0.01) and LSMM (OR = 3.04, 95% CI: 1.17-7.89; p = 0.02). Conclusions: High serum myostatin levels increase the risk of LSMM and rheumatoid cachexia. We propose that high myostatin levels are useful biomarkers for the identification of patients in risk of rheumatoid cachexia and myopenia.

Dimensiones culturales del concepto pie diabético en personas con diabetes mellitus y en estudiantes de medicina mexicanos / Cultural Dimensions of the Diabetic Foot Concept in People with Diabetes Mellitus and in Mexican Medical Students

RESUMEN Objetivo: Analizar las dimensiones culturales del concepto pie diabético en personas con diabetes mellitus y en estudiantes de medicina. Material y métodos: Estudio descriptivo exploratorio con base en los fundamentos de la antropología cognitiva y la teoría del consenso cultural. Participaron 40 personas (20 personas con diabetes y 20 estudiantes de medicina de séptimo semestre). El estudio se realizó en Guadalajara (México), en un hospital de segundo nivel, en los primeros tres meses de 2019. Se utilizaron listados libres y pile sort para identificar el contenido y la organización de las dimensiones. En el caso de los valores agregados, las matrices fueron analizadas mediante conglomerados jerárquicos. En el caso de los valores individuales, las matrices fueron analizadas mediante un modelo de consenso cultural. Resultados: Para las personas con diabetes, el concepto de pie diabético se conformó por las dimensiones de consecuencias y prevención. Para los estudiantes de medicina, el concepto de pie diabético se conformó por las dimensiones consecuencias y complicaciones. Se encontró consenso cultural en ambos grupos (Razón F1:F2, personas con diabetes: 3.14; estudiantes de medicina: 6.73). Las dimensiones tuvieron valores de ajuste adecuados: stress 0.21 en las personas con diabetes y 0.13 en los estudiantes. Conclusiones: Gracias a los resultados y acercamiento hacia ambos grupos, se pudieron reconocer elementos claves para la futura aplicación de programas de prevención para la salud, y una atención más integral para las personas con diabetes mellitus.

ABSTRACT Objective: Analyze the cultural dimensions of the diabetic foot concept in people with diabetes mellitus and in medical students. Material and Methods: Exploratory descriptive study based on the foundations of cognitive anthropology and the theory of cultural consensus. Forty people participated (20 people with diabetes and 20 medical students in the seventh semester). The study was conducted in Guadalajara, Mexico, in a second level hospital, in the first three months of the year 2019. Free lists and pile sort were used to identify the content and the organization of the dimensions. In the case of the aggregated values, hierarchical conglomerates analyzed the matrices. In the case of individual values, the matrices were analyzed using a cultural consensus model. Results: People with diabetes mellitus conformed the concept of diabetic foot by the dimensions of consequences and complications, whereas the medical students conformed the concept by the dimensions of consequences and complications. The cultural consensus was found in both groups with the following reasons F1:F2, people with diabetes: 3.14; medical students: 6.73. The dimensions had adequate values with the stress of 0.21 for the people with diabetes, and of 0.13 for the medical students. Conclusions: Gratefully, these results and the approach towards these two groups' key elements could be found for a future application of programs of health prevention and deeper and integral treatment process for the people with diabetes mellitus.

Structure and content of the maternal representations of Mexican teenagers during their first pregnancy / Estructura y contenido de las representaciones maternas de adolescentes mexicanas durante su primer embarazo

Abstract Objectives: understand the structure and content of the maternal representations of Mexican teenagers during their first pregnancy. Methods: a study was carried out with qualitative methodology based on the concept of maternal representation and the theory of social representations with 30 adolescents who attended prenatal control at the Civil Hospital of Guadalajara "Fray Antonio Alcalde", in Jalisco, Mexico. The participants were interviewed with the consent of their tutors. Classical content analysis techniques were used to obtain codes and thematic categories to develop a conceptual map that explains maternal representations. Results: the maternal representation was identified: "Pregnant but reunited, a legitimated bad decision", which was composed of social meanings towards adolescent pregnancy, family dynamics, expectations towards motherhood, and the feelings experienced by the adolescent during the pregnancy. The content of the representations was heterogeneous for most of the identified categories; however, it is identified that the desire for pregnancy guides the expectations of the adolescent about her future way of being as a mother. Conclusions: the desire of women for pregnancy, the level of participation of the couple, and the social meanings of adolescent pregnancy, have an outstanding role in the development of models of maternal representations.

Resumen Objetivos: comprender la estructura y contenido de las representaciones maternas de adolescentes mexicanas durante su primer embarazo. Métodos: se llevó a cabo un estudio con metodología cualitativa basado en el concepto de representación materna y la teoría de las representaciones sociales con 30 adolescentes que asistieron a control prenatal al Hospital Civil de Guadalajara "Fray Antonio Alcalde", ubicado en Jalisco, México. Las participantes fueron entrevistadas con previo consentimiento de sus tutores. Se utilizaron técnicas de análisis de contenido clásico para obtener códigos y categorías temáticas para desarrollar un mapa conceptual que explique las representaciones maternas. Resultados: se identificó la representación materna: "Embarazada pero juntada, una mala decisión legitimada", la cual se compuso de significados sociales hacia el embarazo adolescente, la dinámica familiar, las expectativas hacia la maternidad, y los sentimientos vividos por la adolescentedurante el embarazo. El contenido de la representación materna fue heterogéneo, empero, se identificó que el deseo por el embarazo guía las expectativas de la adolescente sobre su futura manera de ser madre. Conclusiones: el deseo de la mujer por el embarazo, el nivel de participación de la pareja, y los significados sociales del embarazo adolescente, tienen un papel sobresaliente en el desarrollo de las representaciones maternas.

Validación en español del instrumento Core competencies for public health professionals en Guadalajara (Jalisco, México) / Spanish validation of the «Core Competencies for Public Health Professionals» tool in Guadalajara, Jalisco, Mexico

OBJETIVO: Validar en español el instrumento Core competencies for public health professionals (CCPHP), en población de Guadalajara (Jalisco, México). MÉTODO: Estudio transversal. Se tradujo al español el instrumento CCPHP. Se aplicó a una muestra propositiva de 460 estudiantes de medicina y 460 expertos en salud pública. Se determinó la validez de constructo y la consistencia interna y externa del instrumento con el 95% de confianza (p ≤ 0,05). RESULTADOS: La muestra la formaron 460 estudiantes de medicina (62,1% femeninos y 37,9% masculinos), con edad media de 19,55 ± 0,87 años y 460 expertos en salud pública (50% femeninos y 50% masculinos), con edad media de 52,20 ± 10,26 años, el 90% con doctorado y el 10% con posdoctorado. La consistencia interna fue del 89% (alfa de Cronbach = 0,890) y la consistencia externa del 80,4% (ρ de Spearman = 0,804). En cuanto a la validez de constructo: mediana en estudiantes 195; intervalo 113-332; mediana en expertos 281,5; intervalo 226-365; U de Mann-Whitney = 34,5 (p < 0,001). CONCLUSIONES: El CCPHP en español demostró elevadas consistencias interna y externa, así como validez de constructo. Al carecer de un estándar de oro, es necesario comparar los resultados de este instrumento con pruebas objetivas de esta competencia para sustentar su validez de criterio

OBJECTIVE: To validate the «Core Competencies for Public Health Professionals» (CCPHP) tool in Spanish in a population from Guadalajara, Jalisco, Mexico. METHODS: A cross-sectional study was conducted after translating the CCPHP tool into the Spanish language. It was then applied to a purposing sample of 460 medical students and 460 public health experts. The tool construct validity, as well as internal and external consistency, was determined, with 95% of confidence limits (p ≤ 0.05). RESULTS: The study included a total of 460 medicine students, 62.1% females and 37.9% males, with mean age 19.55 ± 0.87 years. As regards the 460 public health experts, of whom 50% were females and 50% males, with mean age 52.20 ± 10.26 years, there 90% with a doctorate degree and 10% with post-doctorate degree. Internal consistency: 89% (Alpha de Cronbach = 0.890). External consistency: 80.4% (Spearman ρ = 0.804). Construct validity: student median 195, interval 113-332, expert median 281.5, interval 226-365, Mann-Whitney's U = 34.5 (P <.001). CONCLUSIONS: The CCPHP in Spanish showed high internal and external consistencies, as well as construct validity. Lacking a gold standard, a comparison of the results of this tool against objective evidence of this competency is needed in order to sustain its criterion validity

Efecto de un plan de estudios de Medicina sobre las competencias para la promoción de la salud y la participación social / Effect of a medical curriculum on the competencies for promotion of health and social participation

OBJETIVO: Evaluar el efecto del plan de estudios de la Licenciatura en Medicina de la Universidad Guadalajara LAMAR sobre las competencias profesionales para la promoción de la salud y la participación social. MATERIAL Y MÉTODOS: Estudio cuasiexperimental de tipo preexperimental de comparación con un grupo estático. Emplazamiento: Campus Vallarta. Temporalidad: septiembre-diciembre de 2017. Universo: 182 estudiantes de Medicina. Muestra: no probabilística, n = 114 estudiantes de Medicina, 62 de primer semestre (G1, intervención momento «A») y 52 de sexto semestre (G2, intervención momento «B»), más 50 estudiantes de primer semestre de licenciatura no relacionada con salud (G0, control). Muestreo: propositivo. Criterios de selección: cualquier edad y sexo, y responder instrumentos. VARIABLES: edad, sexo y competencias profesionales para la promoción de la salud y la participación social. Instrumentos: Instrumento en Español para Evaluar Prácticas de Salud Pública. Procedimientos: las evaluaciones se realizaron al término del semestre 2017B. Análisis: comparación mediante estadística inferencial no paramétrica (p ≤ 0,05). RESULTADOS: Niveles de competencias profesionales para la promoción de la salud y participación social: G0 100% poco o nada competentes, G1 64,5% poco o nada competentes y 35,5% medianamente competentes, G2 11,5% poco o nada competentes y 88,5% medianamente competentes. El nivel de competencia fue mayor al estar expuestos al plan de estudios, y aumentó a mayor tiempo de exposición (Chi2, p ≤ 0,05 en todos los casos). CONCLUSIONES: El plan de estudios de Medicina evaluado desarrolla en sus estudiantes competencias profesionales para la promoción de la salud y la participación social, pero es susceptible de ser mejorado

OBJECTIVE: To evaluate the effect of medical curriculum from Universidad Guadalajara LAMAR over professional competencies for promotion of health and social participation in medical students. MATERIAL AND METHODS: Quasi-experimental study type pre-experimental of comparison with static group. Emplacement: Vallarta's Campus. Temporality: September-December 2017. Universe: 182 medical students. Sample: non-randomized, n = 114 medical students, 62 from first semester (G1, intervention's moment "A") and 52 from sixth semester (G2, intervention's moment "B"), and additionally 50 from first semester of bachelor not related with health (G0, control). Sampling: propositive. Selection criteria: any age and gender, and to answer instruments. VARIABLES: age, gender and professional competencies for promotion of health and social participation. Instruments: Instrument in Spanish for to Evaluate Public Health Practices. Procedures: the evaluation it achieved to term of 2017B scholar cycle. Analysis: comparison by mean of non-parametric inferential statistics (P ≤ 0.05). RESULTS: Professional competencies level for promotion of health and social participation: G0 100% little or nothing competent, G1 64.5% little or nothing competent and 35.5% fairly competent, G2 11.5% little or nothing competent and 88.5% fairly competent. The competency level was higher in exposed to medical curriculum and increased to a longer exposure time (Chi2, P ≤ 0.05 in all cases). CONCLUSIONS: The medical curriculum from Universidad Guadalajara LAMAR develop professional competencies for promotion of health and social participation in your students, but this can be improved because nobody was highly competent

Riesgo para el desarrollo de trastorno depresivo mayor al existir alteraciones en la sintomatología menopaúsica en mujeres de Guadalajara, Jalisco / Risk for the development of major depressive disorder when there are alterations in menopausal symptoms in women from Guadalajara, Jalisco

RESUMEN Antecedentes: El Trastorno Depresivo Mayor (TDM) puede presentarse durante el inicio de la menopausia, variando su prevalencia de acuerdo a diferentes factores de riesgo clínicos y sociodemográficos; presentándose una mayor asociación al existir alteraciones en la sintomatología menopaúsica. Ante esto, se buscará determinar el riesgo para desarrollar TDM al presentar alteraciones en la sintomatología menopaúsica. Metodología: Es un diseño transversal analítico que incluyó a 252 mujeres iniciando su menopausia (48±1.7 años), atendidas en centros de salud de Guadalajara, Jalisco. Las variables analizadas fueron antecedentes sociodemográficos, utilizando el Inventario de Depresión de Beck para identificar el TDM y la Escala de Valoración de la Menopausia para determinar alteraciones en los principales dominios sintomatológicos de la menopausia. Se realizaron análisis descriptivos y de asociación por medio de Odds Ratio (OR), aplicando finalmente una regresión logística. Resultados: La prevalencia de TDM fue de 40.5%, teniendo asociación con el antecedente de uso de anticonceptivos y con el agravamiento en la sintomatología menopaúsica. El análisis ajustado determinó que hay más riesgo de presentar TDM cuando existen alteraciones en los dominios sintomatológicos, tales como en el somático (OR 3.96, IC95% 1.58-9.95), el urogenital (OR 4.29, IC95% 2.13-8.65) y el psicológico (OR 13.55, IC95% 3.97-46.30). Conclusión: La presencia de alteraciones en la sintomatología menopaúsica se encuentra asociado con un mayor riesgo de presentar TDM, sobre todo si el dominio psicológico está afectado, por lo cual es necesario que el personal de salud identifique estas alteraciones y brinde un manejo temprano en esta etapa de la vida.

ABSTRACT Background: Major Depressive Disorder (MDD) can occur during the onset of the menopause, varying its prevalence according to different clinical and sociodemographic risk factors; presenting a greater association with the existence of alterations in the menopausal symptomatology. Given this, we will seek to determine the risk to develop MDD by presenting alterations in the menopausal symptoms Methodology: It is an analytical cross-sectional design that included 252 women beginning their menopause (48±1.7 years old), and who were attended in health centers of Guadalajara, Jalisco. The analyzed variables were their sociodemographic background, using the Beck Depression Inventory to identify the MDD and the Menopause Rating Scale to determine alterations in the main symptomatological domains of the menopause. Descriptive and association analyzes were performed by means of Odds Ratio (OR), subsequently applying a logistic regression model. Results: The prevalence of MDD was 40.5%, with significant associations with the history of contraceptive use and the worsening of menopausal symptoms. The adjusted analysis allowed us to determine that there is more risk for developing MDD when there were alterations in the symptomatological domains, such as in the somatic (OR 3.96, 95% CI 1.58-9.95), the urogenital (OR 4.29, IC95% 2.13-8.65) and in the psychological (OR 13.55, IC95% 3.97-46.30). Conclusion: The presence of alterations in the menopausal symptomatology is associated with an increased risk of developing MDD, especially if the psychological domain is affected, which is why it is necessary for health personnel to identify these alterations and provide early management in this stage of live.

Consumo diferenciado de macronutrientes según sexo y edad en estudiantes de educación superior / Differentiated consumption of macronutrients according to sex and age in higher education students

RESUMEN Objetivo Analizar la ingesta de macronutrientes y su relación con la edad y sexo en estudiantes de educación superior. Métodos Se realizó un estudio transversal conformado con 218 estudiantes de educación superior de 18 a 30 años. Se utilizó un instrumento validado y confiable, para medir el consumo de macronutrientes. Resultados Respecto a la ingesta de consumo de macronutrientes se observa que hay diferencia estadística por sexo, a favor de los hombres (p>0,05), excepto en el consumo de proteínas en los estudiantes mayores de 25 años. En el grupo etario menor a 20 años, los hombres tienen un mejor consumo de proteínas. En estudiantes de 20 a 25 años el consumo de macronutrientes es parecido entre hombres y mujeres. Discusión Los resultados evidencian que el porcentaje de consumo respecto del valor ideal de requerimiento estimado para actividad ligera según FAO/OMS/ONU 2004, está por debajo, con un déficit de consumo de macronutrientes que oscila entre el 20% y el 60%.(AU)

ABSTRACT Objective To analyze the intake of macronutrients and its relationship with age and sex in higher education students. Materials and Methods A cross-sectional study was carried out with 218 higher education students, aged between 18 and 30 years. A validated and reliable instrument was used to measure macronutrient consumption. Results Regarding the intake of macronutrients, a statistical difference by sex was observed in favor of men (p>0.05), except for the consumption of proteins in students older than 25 years. In the group under 20 years of age, men showed better protein intake. Finally, in students between 20 and 25 years, the consumption of macronutrients is similar among men and women. Discussion The results show that the percentage of consumption with respect to ideal value of the estimated requirement for light activity according to FAO/WHO/UN 2004 is below the recommendations, with a macronutrient consumption deficit that ranges between 20% and 60%.(AU)

[Mortalidad por enfermedad de Alzheimer en México de 1980 a 2014].

BACKGROUND: Dementias are rarely considered to be a main cause of death; therefore there are only few studies on Alzheimer's mortality covering long periods. OBJECTIVE: To describe mortality from Alzheimer's disease in México for the period from 1980 to 2014. METHOD: Cross-sectional study where, with official mortality data in Mexico according to codes 331.0 and G30, respectively, of the 9th and 10th revisions of the International Statistical Classification of Diseases and Related Health Problems, crude and standardized Alzheimer's disease mortality rates were obtained, both nationally and by states. RESULTS: From almost being inexistent, deaths from Alzheimer's disease went to a rate of 65.12 per 1000 females and 43.66 per 1000 males in the 2010-2014 five-year period. Throughout the study period, the age group with highest mortality rates for this cause were those older than 80 years, with 0.29 per 100,000 population in 1980-1984 and 55.02 in 100,000 in the 2010-2014 period. The region with the highest mortality was the northwest, with rates higher than 2.28 per 100,000 population. CONCLUSIONS: Mortality from Alzheimer's disease is a public health problem in Mexico with a growing trend, especially among women and older adults. Early diagnostic measures and opportune treatment are required in primary care in order to reduce this problem.

INTRODUCCIÓN: Raramente se considera a las demencias como causa principal de muerte, por consiguiente existen pocos estudios sobre la mortalidad por Alzheimer a través de largos periodos. OBJETIVO: Describir la mortalidad por enfermedad de Alzheimer en México durante el periodo 1980-2014. MÉTODO: Estudio transversal en el que, con datos oficiales de mortalidad en México según los códigos 331.0 y G30 de la novena y décima revisiones de la Clasificación Estadística Internacional de Enfermedades y Problemas Relacionados con la Salud, se obtuvieron tasas crudas y estandarizadas de mortalidad por enfermedad de Alzheimer, nacional y por entidad federativa. RESULTADOS: De ser casi inexistentes, en el quinquenio 2010-2014 se registraron tasas de 65.12 y 43.66 muertes por enfermedad de Alzheimer por cada 1000 mujeres y 1000 hombres, respectivamente. En todo el periodo estudiado, el grupo etario con las mayores tasas de mortalidad por esta causa fue el de mayores de 80 años, con 0.29 en 100 000 habitantes durante 1980-1984 y 55.02 durante 2010-2014. La región con mayor mortalidad fue la noroeste, con tasas mayores a 2.28 en 100 000 habitantes. CONCLUSIONES: La mortalidad por enfermedad de Alzheimer es un problema de salud pública en México con tendencia creciente, especialmente entre mujeres y adultos mayores. Se requieren medidas diagnósticas precoces y tratamiento oportuno en primer nivel para aminorar este problema.

Prescripción inadecuada de medicamentos: aportaciones de los paradigmas científicos a su conocimiento / Inadequate drugs prescription: contributions of scientific paradigms to your knowledge

Resumen Se realizó una revisión narrativa con análisis temático sobre las aportaciones de los paradigmas científicos al conocimiento de la prescripción inadecuada de medicamentos. Se buscaron artículos de acceso abierto indexados en PubMed© entre 2010-2014, y se sistematizó información sobre el paradigma, tipo de publicación, perspectiva teórica, objetivo, método y resultados. De los 992 artículos encontrados, se seleccionaron 118, y se tomó una muestra propositiva de 15, según su diseño, representando los cuatro paradigmas. Los artículos positivistas reportaron prevalencia, factores asociados, efectividad de intervenciones y criterios de evaluación; los interpretativos explicaron las causas del problema según los involucrados; los críticos denunciaron la influencia de la industria farmacéutica; y el participativo abordó el problema secundariamente y lo solucionó en un escenario para una enfermedad y grupo farmacológico específicos. Se concluyó que la prescripción inadecuada de medicamentos como problema de investigación en salud pública recibe aportes de los cuatro paradigmas, con dominio del positivismo, lo que se atribuye al carácter paradigmático de la ciencia desde la que se le aborda habitualmente, y que una perspectiva multi-paradigmática es el mejor abordaje.

Abstract This study conducted a narrative review with thematic analysis about contributions of scientific paradigms to knowledge of inadequate drugs prescription. We searched open access articles indexed in PubMed© between 2010 and 2014, and we systematized information about scientific paradigm, publication type, theoretical perspective, objective, method and results. From the 992 articles found, 118 were selected. From those, we chose a purposive sample of 15, according to the design of the studies, representing the four paradigms. The positivists articles reported prevalence, associated factors, effectiveness of interventions and evaluation criteria; the interpretive explained the causes of the problem according to those involved; the critics denounced the influence of pharmaceutical industry; and the participative addressed the problem secondarily and solved it in a scenario for a specific disease and pharmacological. We concluded that the inadequate drugs prescription as research problem in public health had contributions from the four paradigms, with dominance of positivism, which is attributed to the paradigmatic perspective of the science, from which it is usually studied, and that a multi-paradigmatic perspective is the best approach to the public health issue.

[Differentiated consumption of macronutrients according to sex and age in higher education students]. / Consumo diferenciado de macronutrientes según sexo y edad en estudiantes de educación superior.

OBJECTIVE: To analyze the intake of macronutrients and its relationship with age and sex in higher education students. MATERIALS AND METHODS: A cross-sectional study was carried out with 218 higher education students, aged between 18 and 30 years. A validated and reliable instrument was used to measure macronutrient consumption. RESULTS: Regarding the intake of macronutrients, a statistical difference by sex was observed in favor of men (p>0.05), except for the consumption of proteins in students older than 25 years. In the group under 20 years of age, men showed better protein intake. Finally, in students between 20 and 25 years, the consumption of macronutrients is similar among men and women. DISCUSSION: The results show that the percentage of consumption with respect to ideal value of the estimated requirement for light activity according to FAO/WHO/UN 2004 is below the recommendations, with a macronutrient consumption deficit that ranges between 20% and 60%.

OBJETIVO: Analizar la ingesta de macronutrientes y su relación con la edad y sexo en estudiantes de educación superior. MÉTODOS: Se realizó un estudio transversal conformado con 218 estudiantes de educación superior de 18 a 30 años. Se utilizó un instrumento validado y confiable, para medir el consumo de macronutrientes. RESULTADOS: Respecto a la ingesta de consumo de macronutrientes se observa que hay diferencia estadística por sexo, a favor de los hombres (p>0,05), excepto en el consumo de proteínas en los estudiantes mayores de 25 años. En el grupo etario menor a 20 años, los hombres tienen un mejor consumo de proteínas. En estudiantes de 20 a 25 años el consumo de macronutrientes es parecido entre hombres y mujeres. DISCUSIÓN: Los resultados evidencian que el porcentaje de consumo respecto del valor ideal de requerimiento estimado para actividad ligera según FAO/OMS/ONU 2004, está por debajo, con un déficit de consumo de macronutrientes que oscila entre el 20% y el 60%.

Clinical competence of Guatemalan and Mexican physicians for family dysfunction management.

OBJECTIVE: To evaluate the clinical competence of Mexican and Guatemalan physicians to management the family dysfunction. METHODS: Cross comparative study in four care units first in Guadalajara, Mexico, and four in Guatemala, Guatemala, based on a purposeful sampling, involving 117 and 100 physicians, respectively. Clinical competence evaluated by validated instrument integrated for 187 items. Non-parametric descriptive and inferential statistical analysis was performed. RESULTS: The percentage of Mexican physicians with high clinical competence was 13.7%, medium 53%, low 24.8% and defined by random 8.5%. For the Guatemalan physicians'14% was high, average 63%, and 23% defined by random. There were no statistically significant differences between healthcare country units, but between the medium of Mexicans (0.55) and Guatemalans (0.55) (p = 0.02). CONCLUSION: The proportion of the high clinical competency of Mexican physicians' was as Guatemalans.

Efecto de una intervención educativa para promover ejercicios aeróbicos intradialíticos, sobre el estado funcional en pacientes en hemodiálisis de México / Effect of an educational intervention to promote intradialysis aerobic exercises on the functional state of hemodialysis patients from Mexico

INTRODUCCIÓN: La educación en salud busca influir sobre la actitud de las personas para mejorar su salud mediante el fomento de hábitos saludables. En pacientes en hemodiálisis, su capacidad funcional suele estar disminuida por la inactividad física. OBJETIVO: Evaluar el efecto de una intervención educativa en salud para la promoción del ejercicio aeróbico, sobre la capacidad funcional de pacientes en hemodiálisis de México. MATERIAL Y MÉTODOS: Estudio cuasiexperimental antes-después con grupo control en Unidades de Atención Médica Hospitalaria del Instituto Mexicano del Seguro Social, Delegación Jalisco, con un universo de 26 pacientes con hemodiálisis muestreados propositivamente, 14 en el Grupo "A" (experimental) y 12 en el "B" (control). Se incluyeron las variables: edad, sexo y capacidad funcional. La intervención consistió en un diálogo dirigido sobre factores biopsicosociales de enfermedad renal, capacidad funcional y nutrición, con acompañamiento en ejercicios aeróbicos de 30 minutos/semana durante 20 semanas. Se evaluó la capacidad funcional con el Test Delta, y se comparó la media antes y después usando T de Student (p ≤ 0,05). RESULTADOS: No hubo diferencias estadísticamente significativas entre la edad y sexo de los pacientes en los Grupos "A" y "B". Capacidad funcional media antes y después: Grupo "A" 14 ± 5 vs 8 ± 4 (p < 0,001), Grupo "B" 16 ± 4 vs 17 ± 5 (p = 0,405). Conclusiones: La educación en salud influyó favorablemente sobre la actividad física de los pacientes en hemodiálisis y mejoró su capacidad funcional. Es recomendable implementar programas de ejercicio aeróbico durante las sesiones de hemodiálisis

INTRODUCTION: Health education search to influence on persons' attitude for to improve your health by mean of healthy habits promotion. In patients with hemodialysis your functional capacity usually is diminished for physical inactivity. OBJECTIVE: To evaluate the effect of a health education intervention for aerobic exercise's promotion on the functional capacity in hemodialysis patients from Mexico. METHODS: Quasi-experimental study beforeafter with control group in Hospital Medical Care Units of the Mexican Institute of Social Security, Jalisco's Delegation, with a universe of 26 patients with hemodialysis purposively sampled, 14 in Group "A" (experimental) and 12 in Group "B" (control). It included variables: age, gender and functional capacity. The intervention consisted of directed dialogue on biopsychosocial factors of renal disease, functional capacity and nutrition, with accompaniment in aerobic exercises of 30 minutes/week for 20 weeks. It evaluated functional capacity with Delta Test and it compared means before and after with Student's T (p ≤ 0,05). Results: There were no statistically significant differences between age and gender of patients in the "A" and "B" Groups. Mean functional capacity before and after: Group "A" 14 ± 5 vs 8 ± 4 (p < 0,001), Group "B" 16 ± 4 vs 17 ± 5(p=0,405). CONCLUSIONS: The health education influenced favorably on the physical activity of patients with hemodialysis and improved your functional capacity. To implement aerobic exercise programs during hemodialysis sessions it advisable

Efectividad de las intervenciones para mejorar la prescripción de medicamentos en atención primaria / Effectiveness of interventions for improving drug prescribing in Primary Health Care

OBJETIVO: Determinar la efectividad de las intervenciones para mejorar la calidad de la prescripción de medicamentos en unidades de atención primaria. DISEÑO: Revisión sistemática y meta-análisis. Fuentes de datos. Se buscó en MedLine, ScienceDirect, Springer, SciELO, Dialnet, RedALyC e Imbiomed en español, inglés y portugués, usando los descriptores: «calidad de la prescripción», «estudios de intervención» y «atención primaria», desde la indexación de cada base de datos hasta agosto de 2014. Selección de estudios. Se incluyeron estudios experimentales y cuasi-experimentales con puntuación CASPe>5, en los que se evaluó el efecto de una intervención de cualquier tipo sobre la calidad de la prescripción de tratamientos farmacológicos en atención primaria. RESULTADOS: Se encontraron 522 artículos de los que se analizaron 12 que reportaron 17 intervenciones: 64,7% educativas, 23,5% incorporación de farmacéuticos y 11,8% informáticas. Las fuerzas de asociación «intervención/mejora» fueron: intervenciones educativas OR=2,47 (IC 95%: 2,28 a 2,69), incorporación de farmacéuticos OR=3,28 (IC 95%: 2,58 a 4,18) e intervenciones informáticas OR=10,16 (IC 95%: 8,81 a 11,71). CONCLUSIONES: Las intervenciones informáticas son más efectivas que las educativas y la incorporación del farmacéutico. Se requiere incorporar a los estudios de intervención variables alusivas al coste de implementación, gasto en medicamentos y otros gastos relacionados con la atención a la salud y el tratamiento de las enfermedades

OBJECTIVE: To determine the effectiveness of interventions for improving drug prescribing in Primary Health Care units. DESIGN: Systematic review and meta-analysis. Data sources. Searches were made in MedLine©, ScienceDirect©, Springer©, SciELO©, Dialnet©, RedALyC© and Imbiomed©, in Spanish, English and Portuguese, using keywords «drug prescribing», «intervention studies» and «primary health care», indexed in each data base up to August 2014. Selection of studies. Experimental and quasi-experimental studies were included that had a CASP-score>5 and that evaluated effect of any type intervention on the quality of drug prescription in Primary Health Care. RESULTS: A total of 522 articles were found, and an analysis was performed on 12 that reported 17 interventions: 64.7% educational, 23.5% incorporating pharmacists into the health team, and 11.8% on the use of computer applications. The strong «intervention/improvement» associations were educational interventions OR=2.47 (95% CI; 2.28 - 2.69), incorporation of pharmacists OR=3.28 (95% CI; 2.58 4.18), and use of computer applications OR=10.16 (95% CI; 8.81 -11.71). CONCLUSIONS: The use of interventions with computer applications showed to be more effective than educational interventions and incorporation pharmacists into the health team. Future studies are required that include economic variables such as, implementation costs, drug costs and other expenses associated with health care and treatment of diseases

[Effectiveness of interventions for improving drug prescribing in Primary Health Care]. / Efectividad de las intervenciones para mejorar la prescripción de medicamentos en atención primaria.

OBJECTIVE: To determine the effectiveness of interventions for improving drug prescribing in Primary Health Care units. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Searches were made in MedLine©, ScienceDirect©, Springer©, SciELO©, Dialnet©, RedALyC© and Imbiomed©, in Spanish, English and Portuguese, using keywords "drug prescribing", "intervention studies" and "primary health care", indexed in each data base up to August 2014. SELECTION OF STUDIES: Experimental and quasi-experimental studies were included that had a CASP-score>5 and that evaluated effect of any type intervention on the quality of drug prescription in Primary Health Care. RESULTS: A total of 522 articles were found, and an analysis was performed on 12 that reported 17 interventions: 64.7% educational, 23.5% incorporating pharmacists into the health team, and 11.8% on the use of computer applications. The strong "intervention/improvement" associations were educational interventions OR=2.47 (95% CI; 2.28 - 2.69), incorporation of pharmacists OR=3.28 (95% CI; 2.58 4.18), and use of computer applications OR=10.16 (95% CI; 8.81 -11.71). CONCLUSIONS: The use of interventions with computer applications showed to be more effective than educational interventions and incorporation pharmacists into the health team. Future studies are required that include economic variables such as, implementation costs, drug costs and other expenses associated with health care and treatment of diseases.

Clinical competencies for primary health care of climacteric in a group of Mexican physicians / Competências clínicas para cuidados de saúde primários de climatério em um grupo de médicos Mexicanos

Objective: Measure clinical competence for female climacteric diagnosis and treatment in physicians from a Mexican social security system. Methods: Cross-sectional and multi-centric study in 78 physicians from five primary health care units from the Mexican Institute of Social Security in Guadalajara City, Jalisco, Mexico. We measured clinical competence with an instrument specially designed and validated (reliability p = 0.92 accord to Kuder­Richardson test). We obtained descriptive statistics and compared proficiency level accord to labor, demographic and academic characteristics using no-parametric statistic. Results: Clinical competencies medians in five primary health care units were 8­21 points in a scale with maximum value of 108. We do not found significant differences to compare medical unit, gender, specialty, previous training in female climacteric symptoms, contract type, workshift and medical certifications (p > 0.05). Conclusions: Climacteric clinical competence is null or very low in primary health care physicians from Guadalajara City. Educational interventions are required.(AU)

Objetivo: Medir competência clínica para o diagnóstico e tratamento do climatério feminino nos médicos a partir de um sistema de segurança social mexicano. Métodos: Estudo transversal e multicêntrico com 78 médicos de cinco unidades básicas de saúde do Instituto Mexicano de Segurança Social na Cidade de Guadalajara, Jalisco, México. Medimos competência clínica com um instrumento especialmente concebido e validado (confiabilidade p = 0,92 de acordo com o teste de Kuder-Richardson). Obtivemos estatística descritiva e comparação do nível de proficiência no trabalho de acordo com as características demográficas e acadêmicas com o uso do método não paramétrico. Resultados: Competências clínicas medianas em cinco unidades básicas de saúde foram de 8 a 21 pontos em uma escala com valor máximo de 108. Não se encontraram diferenc¸as significativas para comparar unidade médica, sexo, especialidade, treinamento prévio em sintomas do climatério feminino, tipo de contrato, turno de trabalho e certificações médicas (p > 0,05). Conclusões: Competência clínica para o diagnóstico e tratamento do climatério é nula ou muito baixa em cuidados médicos primários de saúde na Cidade de Guadalajara. Intervenções educativas são necessárias.(AU)

[Clinical competence measurement in Mexican resident physicians for diagnosis and treatment of Chagas disease]. / Evaluación de la competencia clínica en médicos residentes mexicanos para el diagnóstico y tratamiento de la enfermedad de Chagas.

OBJECTIVE: Evaluate clinical competence of a mexican resident physicians sample for diagnosis and treatment of Chagas disease. MATERIAL AND METHODS: Cross-sectional and analytic study in 122 resident physicians of epidemiology, family medicine and internal medicine specialty, assigned to a third level medical unit from Guadalajara, Jalisco, Mexico, taking a sample for convenience. An instrument was designed and validated for to evaluate clinical competence in five dimensions: risk factors identification, clinical data identification, diagnostic test interpretation, diagnostic integration and therapeutic resources utilization; that classified competence level in four strata: random defined, low, medium and high, with 89% of reliability accord to Kunder-Richardson test. Descriptive and no parametric inferential statistics were obtained. RESULTS: A total of 122 physicians, 55.7% males (n = 68) and 44.3% females (n = 54). Random defined clinical competence 4.9% (n = 6), low 49.2% (n = 60), medium 44.3% (n = 54) and high 1.6% (n = 2). Median significantly higher in epidemiologists (p = 0.03). CONCLUSIONS: Improve clinical competence level of resident physicians for diagnosis and treatment of Chagas disease is necessary. Intervention studies are required.

[Mortality due to traffic injuries and its impact on life expectancy: a comparison between Mexico and Spain]. / Mortalidad por lesiones de tráfico y su impacto en la esperanza de vida: comparativa entre México y España.

OBJECTIVE: To determine the impact of mortality due to motor vehicle traffic injuries (MVTI) compared with other causes of death on life expectancy in Mexico and Spain during the three-year periods 2000-2002 and 2010-2012 and the weight of the different age groups in years of life expectancy lost (YLEL) due to this cause. METHODS: Based on official death and population data, abridged life tables in Mexico and Spain were constructed for the three-year periods studied. Temporary life expectancy and YLEL for persons aged 15 to 75 years were calculated by selected causes (MVTI, diabetes mellitus, malignant neoplasms and ischemic heart diseases) and age groups in each three-year period. RESULTS: In Spain, YLEL decreased in both sexes from all the causes studied, especially MVTI; this reduction was greater in the younger ages. In addition, temporary life expectancy increased. In Mexico, YLEL due to MVTI increased in men, mainly in young people, and remained unchanged among women. Temporary life expectancy declined in men but increased slightly among women. CONCLUSIONS: The reduction in YLEL due to MVTI in Spain has contributed to increased life expectancy. By contrast, the increase in YLEL due to MVTI among Mexican men has contributed to the decline in male life expectancy.

Mortalidad por lesiones de tráfico y su impacto en la esperanza de vida: comparativa entre México y España / Mortality due to traffic injuries and its impact on life expectancy: a comparison between Mexico and Spain

Objetivo: Determinar el impacto de la mortalidad por lesiones por tráfico de vehículo de motor (LTVM), comparándolo con el de otras causas de muerte, en la esperanza de vida de México y España en los trienios 2000-2002 y 2010-2012, así como el grado de participación de los diferentes grupos de edad en la pérdida de años de esperanza de vida por esta causa. Métodos: A partir de datos oficiales sobre defunciones y población se construyeron tablas de vida abreviadas para México y España en los trienios estudiados. Se calculó la esperanza de vida temporaria y los años de esperanza de vida perdidos (AEVP) en el grupo de 15 a 75 años de edad, por causas seleccionadas (LTVM, diabetes mellitus, tumores malignos y enfermedades isquémicas del corazón) y por grupos de edad en cada trienio. Resultados: En España disminuyeron los AEVP en ambos sexos por todas las causas estudiadas, especialmente por LTVM; esta reducción fue mayor en las edades más jóvenes. Además, se incrementó la esperanza de vida temporaria. En México se incrementaron los AEVP por LTVM en los hombres, principalmente en los jóvenes, y permanecieron igual en las mujeres. La esperanza de vida temporaria masculina se redujo y aumentó ligeramente la femenina. Conclusiones: La reducción de los AEVP por LTVM en España ha contribuido al aumento de la esperanza de vida. Por el contrario, el incremento de los AEVP por LTVM entre los hombres mexicanos ha coadyuvado al descenso de la esperanza de vida masculina (AU)

Objective: To determine the impact of mortality due to motor vehicle traffic injuries (MVTI) compared with other causes of death on life expectancy in Mexico and Spain during the three-year periods 2000-2002 and 2010-2012 and the weight of the different age groups in years of life expectancy lost (YLEL) due to this cause. Methods: Based on official death and population data, abridged life tables in Mexico and Spain were constructed for the three-year periods studied. Temporary life expectancy and YLEL for persons aged 15 to 75 years were calculated by selected causes (MVTI, diabetes mellitus, malignant neoplasms and ischemic heart diseases) and age groups in each three-year period. Results: In Spain, YLEL decreased in both sexes from all the causes studied, especially MVTI; this reduction was greater in the younger ages. In addition, temporary life expectancy increased. In Mexico, YLEL due to MVTI increased in men, mainly in young people, and remained unchanged among women. Temporary life expectancy declined in men but increased slightly among women. Conclusions: The reduction in YLEL due to MVTI in Spain has contributed to increased life expectancy. By contrast, the increase in YLEL due to MVTI among Mexican men has contributed to the decline in male life expectancy (AU)

[Hypothyroidism incidence and thyrotropin serum levels in newborns]. / Incidencia de hipotiroidismo y niveles séricos de la tirotropina en neonatos.

BACKGROUND: congenital hypothyroidism is the third sub-clinic hereditary disease in Mexico. Infants with total or partial underactive thyroid gland presented at birth showed high levels of thyrotropin. This allows identifying patients at risk for developing it through screening tests. The aim was to determinate the incidence of neonatal congenital hypothyroidism in newborns in our hospital as well as set the cut-off value in screening test. METHODS: samples from 4049 cord blood of newborns were processed. TSH was measurement by ELISA. Probands with high values subsequently underwent to confirmatory testing TSH micro-particle immunoassay. RESULTS: the results showed incidence of hypothyroidism of 1.2 per 1000 newborns. The cut-off value obtained in the screening test was 26.63 mUI/L. CONCLUSIONS: TSH values showed a different distribution compared with previous studies in the Mexican population and also a higher hypothyroidism incidence.

Introducción: el hipotiroidismo congénito ocupa el tercer lugar de las enfermedades hereditarias subclínicas en México. Los neonatos con hipofunción total o parcial de la glándula tiroides presentan concentraciones altas de la tirotropina, lo que permite identificar los casos probables con riesgo para desarrollar hipotiroidismo mediante las pruebas de tamiz. El objetivo de esta investigación fue determinar la incidencia de hipotiroidismo congénito neonatal en los recién nacidos y establecer el valor de corte en el ensayo de la prueba de tamiz. Métodos: se procesaron 4049 muestras de sangre de cordón umbilical de recién nacidos. Se cuantificó la hormona estimulante de la tiroides mediante ELISA. A los niños con valores elevados se les realizó la prueba confirmatoria mediante ensayo inmunoenzimático de micropartículas. Resultados: se identificó una incidencia de hipotiroidismo de 1.2 por cada 1000 recién nacidos. El valor de corte para la hormona estimulante de la tiroides fue de 26.63 mUI/L en la prueba de tamiz. Conclusiones: los valores de la hormona estimulante de la tiroides mostraron una distribución diferente a los de otras investigaciones en población mexicana, así como una incidencia más elevada de hipotiroidismo.

Mortalidad por homicidios en México: tendencias, variaciones socio-geográficas y factores asociados / Deaths by homicide in Mexico: trends, socio-geographical variations and associated factors

Este estudio analiza la tendencia de las tasas de homicidio (total y por arma de fuego) en México entre 1990 y 2009 e identifica las variables que mejor explican las variaciones geográficas de las tasas en el bienio 2008-2009. Se calcularon tasas de homicidios, ajustadas por edad, para ambos sexos entre 1990 y 2009, y para cada estado en 2008-2009. El análisis de regresión lineal múltiple fue usado para identificar factores asociados a las variaciones interestatales de las tasas de homicidio. Los resultados muestran que la tasa de homicidio disminuyó entre 1992 y 2007, pero se ha duplicado en los últimos dos años (de 7.6 a 16.6 por 100,000). En 2009, la tasa de homicidio masculina fue cerca de 9 veces mayor que la tasa femenina y casi dos tercios de los homicidios fueron por arma de fuego. El análisis multivariado revela que la impunidad, el narcotráfico, el consumo de alcohol y drogas y la deserción escolar -por ese orden- son factores claves para entender las variaciones geográficas de las tasas de homicidio en México en 2008-2009. Así, para reducir los homicidios y las variaciones espaciales de la tasa, se necesita no solo combatir a los cárteles de la droga sino sobre todo implementar reformas estructurales en el sistema de procuración de justicia y disminuir las disparidades socioeconómicas entre los estados.

This study seeks to analyze the trend of homicide rates (total and by firearm) in Mexico between 1990 and 2009 and identify the variables that best explain the geographical variations of these rates in the 2008-2009 two-year period. Homicide rates, adjusted for age, were calculated for both sexes between 1990 and 2009 and for each state in 2008-2009. Factors associated with the interstate variations in the homicide rates were identified using multiple linear regression analysis. Results show that the homicide rate in Mexico decreased between 1990 and 2007, but doubled over the last two years (from 7.6 to 16.6 per 100,000). In 2009, the male homicide rate was almost 9 times higher than the female rate and about two-thirds of homicides involved firearms. Multivariate analysis reveals that impunity, drug trafficking, alcohol and drug consumption and school dropout in basic education - in that order - are key factors for understanding the geographical variations in homicide rates in Mexico in 2008-2009. Findings suggest that to reduce the number of homicide victims and spatial variations in the rate, it is necessary not only to fight the drug cartels, but above all to implement structural reforms in the criminal justice system and reduce the socioeconomic disparities among states.